4. Known limitationsΒΆ

  • Local minima: To avoid local minima, you can try to increase the number of starting point n_starts.

  • Stiff equations: For some parameter sets, the model ODEs may be very stiff. The implicit Euler scheme used by SBML2Julia may encounter numerical errors. You can try increasing the number of discretization time steps by increasing t_ratio or reducing the parameter search window in the Petab parameter table.